diabetes is effective

Metformin in the treatment of type 1 diabetes is effective what
If patients with type 1 diabetes by continuous insulin therapy on glucose control effect is poor, whether it should be combined with metformin treatment? If need be, when combined with this drug?
If patients with type 1 diabetes by continuous insulin therapy on glucose control effect is poor, whether it should be combined with metformin treatment? If need be,pearl jewelry when combined with this drug?
Insulin therapy in adding a label drug metformin can improve in type 1 diabetic patients on insulin sensitivity, promote its weight control, and reduce the dosage of insulin, existing systematic review to assess this.
A survey designed to assess insulin therapy in adding metformin in type 1 diabetes in adolescent patients. The author through clinical trials database, select some lasted for at least 3 months randomized clinical trials. The authors selected test of metformin combined with insulin and insulin monotherapy efficacy comparison. In 2 trials met the inclusion criteria, a total of 60 patients.
Due to lack of heterogeneity test, can not be conducted meta-analyses, but the author pointed out that the 2 studies were found that metformin combined with insulin treatment can reduce glycosylated hemoglobin A1c level. The study also showed that, taking metformin in patients, insulin dosage is reduced 10%. In the course of combined treatment, the most common adverse reactions to hypoglycemia and functional disorders of the gastrointestinal tract.
Another systematic review assessed the metformin combined with insulin on type 1 diabetes mellitus role. The review identified 9 studies, its object includes both adolescent patients, including adult patients, in the informed consent under random grouping. These studies used parallel or cross design by means of comparing the metformin versus placebo or other reference drug efficacy, duration of at least 1 weeks.
Metformin can reduce the dosage of insulin ( total daily insulin dosage is reduced 5.710.1 unit ), hemoglobin A1c level ( lower 11.615.8 mg / dL ),plastic bag manufacturer weight ( lower 1.76.0 kg ) and total cholesterol levels ( lower 11.615.8 mg / dL ). The 5 study found 6.6 units / day ( P <. 001 ) insulin dosage is reduced significantly, but hemoglobin A1c ( P = 0.42 ) the drop is not obvious, only 0.11%. Based on this, the two drugs of the combination effect of formal assessment. The study also found that the occurrence of low rate assumes the trend of escalation, which assesses research in 2 with statistical significance.
The off-label drug metformin should be combined with insulin in treatment of type 1 diabetes, support and opposition to the relevant clinical trial data are insufficient, but for some patients with type 1 diabetes, in its being accepted by the insulin regimen with metformin may facilitate disease remission. In the patients, in combination with metformin and insulin may have significant clinical implications: overweight,office furniture insulin dosage and / or adherence to insulin treatment and always can not control the level of hemoglobin A1c patients. He should tell the patient when combined with metformin may easily produce hypoglycemia.